Research goals
Our research investigates transcriptional regulation mechanisms that link cardiac stress with altered myocardial fatty acid and glucose metabolism. Our long-term goal pertains to the application of interventions that can improve cardiac function by modulating fatty acid oxidation and energy production.
We are interested in the role of Kruppel-like factors (KLFs) and particularly, KLF5 and its role in the regulation of cardiac fatty acid oxidation during diabetes, myocardial ischemia, ischemia/reperfusion and aging. We also investigate the role of cardiomyocyte KLF5 in regulating systemic metabolism via undiscovered cross-talk mechanisms between the heart, the liver, and the adipose tissue.
Furthermore, we study the role of the cellular energetic machinery in the alleviation of cardiomyopathy in sepsis.
We are interested in the role of Kruppel-like factors (KLFs) and particularly, KLF5 and its role in the regulation of cardiac fatty acid oxidation during diabetes, myocardial ischemia, ischemia/reperfusion and aging. We also investigate the role of cardiomyocyte KLF5 in regulating systemic metabolism via undiscovered cross-talk mechanisms between the heart, the liver, and the adipose tissue.
Furthermore, we study the role of the cellular energetic machinery in the alleviation of cardiomyopathy in sepsis.
Current Lab members
Sobuj Mia
Research Scientist Joined the lab in 2020 |
Georgios Siokatas
PhD student (Aristotle Univ of Thessaloniki) Joined the lab in 2022 |
Kajol Thapa
PhD student (University of Cincinnati) Joined the lab in 2024 |
Erjola Rapushi
MSc student (University of Crete) Joined the lab in 2023 |
Matilda Valianou
Lab manager Joined the lab in 2023 |
Past members
(Photos lead to LinkedIn profiles)
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