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Metabolic Biology Laboratory
Metabolic Biology -Test
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1. What is the main biochemical fuel for cardiac energy production?
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Fatty acids
Glucose
Both fatty acids and glucose.
Glucose but fatty acids in some pathological cases.
Aminoacids
2. How do cells sense the need for energy production?
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Increased phosphorylation of PGC1α
Reduced mitochondrial number
Increased AMP:ATP ratio that leads to AMPK phosphorylation
Increased supply of fatty acids and glucose
Dephosphorylation of AMPK
3. What lipid is toxic for cardiac function?
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Reactive Oxygen Species
Ceramides
Diacylglycerol
All the above
Ceramides and Diacylglycerol
4. What is the goal of hyperlipidemia management?
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Lower Apolipoproteins
Lower triglycerides
Lower cholesterol
All the above
Lower triglycerides and cholesterol
5. A patient with Type 2 diabetes presents with hyperlipidemia and hepatic steatosis. His doctor discusses with you the options for blood lipid lowering and steatosis treatment. What would you suggest?
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CETP inhibitor
KLF5 inhibitor
Fibrates
MTP inhibitors
Ezetimibe & MTP inhibitor
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