MetabolicBiologyTest

Metabolic Biology Laboratory

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Metabolic Biology -Test

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1. What is the main biochemical fuel for cardiac energy production? *

Fatty acids Glucose Both fatty acids and glucose. Glucose but fatty acids in some pathological cases. Aminoacids

2. How do cells sense the need for energy production? *

Increased phosphorylation of PGC1α Reduced mitochondrial number Increased AMP:ATP ratio that leads to AMPK phosphorylation Increased supply of fatty acids and glucose Dephosphorylation of AMPK

3. What lipid is toxic for cardiac function? *

Reactive Oxygen Species Ceramides Diacylglycerol All the above Ceramides and Diacylglycerol

4. What is the goal of hyperlipidemia management? *

Lower Apolipoproteins Lower triglycerides Lower cholesterol All the above Lower triglycerides and cholesterol

5. A patient with Type 2 diabetes presents with hyperlipidemia and hepatic steatosis. His doctor discusses with you the options for blood lipid lowering and steatosis treatment. What would you suggest? *

CETP inhibitor KLF5 inhibitor Fibrates MTP inhibitors Ezetimibe & MTP inhibitor

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